This Policy Note was written by Economics for Health. The policy note assesses the economic costs of alcohol consumption in the six countries which are a part of the RESET Alcohol Initiative: Brazil, Colombia, Kenya, Mexico, Philippines, and Sri Lanka. The findings show that alcohol accounts for 4.5% of DALYs in Brazil, 2.39% in Colombia, 2.54% in Kenya, 3.75% in Mexico, 2.94% in Philippines, and 2.24% in Sri Lanka. The total economic costs associated with alcohol amount to 1.9% of the GDP in Brazil, 1% in Colombia, 1.4% in Kenya, 2.1% in Mexico, 1.5% in the Philippines, and 1% in Sri Lanka. Although these are substantial numbers, they are conservative estimates as they do not include the indirect costs of caregiving and existing research on direct costs of all alcohol-related illness is limited. The policy note concludes with recommendations for policy makers to strengthen alcohol control measures, especially alcohol tax policies, in response to these substantial economic costs.